Operation RAID (Remove Alcohol Impaired Drivers) will target motorists in southern and western NSW, as well as Victoria, South Australia and the ACT from 9am (AEDT) on Friday until 11.59pm on December 16.
Senior Sergeant Mick Timms, NSW Southern Region Traffic Coordinator, said the operation would focus on drink-driving at a time of the year when alcohol made a major contribution to crashes.
He said the combined road toll of the southern and western regions of NSW this year was more than 170.
"This means that next month, more than 170 families will be sitting down for their Christmas dinner with an empty chair at the table," Sgt Timms said.
Over the past four years, Operation RAID officers in NSW have breath-tested more than 320,000 motorists and charged 1,400 people with drink driving and other offences.