Mercedes-Benz E-Class vs Lexus IS

What's the difference?

VS
Mercedes-Benz E-Class
Mercedes-Benz E-Class

$89,855 - $195,970

2025 price

Lexus IS
Lexus IS

$42,999 - $72,999

2021 price

Summary

2025 Mercedes-Benz E-Class
2021 Lexus IS
Safety Rating

Engine Type
Turbo 6, 3.0L

Inline 4, 2.5L
Fuel Type
Premium Unleaded/Electric

Premium Unleaded/Electric
Fuel Efficiency
1.7L/100km (combined)

4.9L/100km (combined)
Seating
5

5
Dislikes
  • No spare tyre
  • Steep service pricing
  • Modest boot

  • Slow
  • Busy interior design
  • Fiddly and over-complicated software
2025 Mercedes-Benz E-Class Summary

You like performance, love a bit of luxury and fancy a traditional sedan. The budget is healthy and there’s a surprising amount of choice. But Mercedes-AMG believes it’s created the car that perfectly answers your new-car brief. 

The Mercedes-AMG E53 Hybrid 4Matic+ is a fresh expression of an established high-performance sedan formula mixing internal-combustion power with electric punch and all-wheel drive.

We were invited to its local launch, so stay with us to see if this newcomer is ready to fill that primo European performance car shaped space in your garage.      

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2021 Lexus IS Summary

One question frequently discussed in the skunkworks of the CarsGuide office is: What exactly does Lexus stand for?

When the brand debuted its original export-market IS sedan in 1999 the messaging was more or less clear: Toyota’s premium sub-brand was here to be a Japanese BMW.

The brand even employed Nobuaki Katayama – chief engineer on the iconic Corolla AE86 program – to again take the reins of its small rear-wheel drive sedan program.

As the years went on though, Lexus changed. Fundamentally geared toward the US market, the second-generation (wild IS F aside) became a bit more sedate and softer around the edges, while the third generation strayed even further from the sedan’s performance-inspired roots, leaning into a plush interior, hybrid drive, and even CVT transmissions.

This brings us to today’s Lexus IS. Essentially a heavy facelift of the third generation (which arrived back in 2013), the brand has “reimagined” its core sedan with a tweaked design and updated technology for 2021.

Is it enough to keep it relevant against its ever-present European rivals and the newly arrived threat from Hyundai’s Genesis G70? I took a signature IS300h hybrid for a week to find out.

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Deep dive comparison

2025 Mercedes-Benz E-Class 2021 Lexus IS

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