Lexus NX vs Mercedes-Benz S450

What's the difference?

VS
Lexus NX
Lexus NX

$56,990 - $103,598

2025 price

Mercedes-Benz S450
Mercedes-Benz S450

$117,488 - $139,800

2021 price

Summary

2025 Lexus NX
2021 Mercedes-Benz S450
Safety Rating

Engine Type
Inline 4, 2.5L

Twin Turbo V6, 3.0L
Fuel Type
Premium Unleaded/Electric

Premium Unleaded Petrol
Fuel Efficiency
1.3L/100km (combined)

8.4L/100km (combined)
Seating
5

5
Dislikes
  • Misses out on a few items for a flagship model
  • Not as flashy inside as rivals
  • Plug-in hybrid powertrain won't win over everyone

  • Price of entry prohibitive for most
  • 3D instrumentation can make you woozy
  • A tad conservative in design
2025 Lexus NX Summary

The Lexus NX 450h+ F Sport is a well-specified and plush-looking medium SUV that has a plug-in hybrid powertrain - a first for the brand.

On paper, it seems to tick the boxes for size, luxury and efficiency but we've been testing the flagship grade to see if it's a winning combo in real life.

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2021 Mercedes-Benz S450 Summary

It's only in the running for the title of world's best luxury car. No biggie here, then.

Like Rolex and Concorde, S-Class has become a byword for ultimate, and deserved or not, the Mercedes-Benz defines its segment despite the best efforts of the BMW 7 Series, Audi A8, Lexus LS and (sadly now-defunct) Jaguar XJ, as well as pointing the way forward with new technologies that eventually trickle down to more proletarian models.

Replacing the half-million selling W222 unveiled in 2013, the W223 is the latest in a long line since the first W187 Ponton debuted in 1951, and includes the famous ‘Finnies' and Stroke-8 models that followed immediately afterwards, but it is the 1972 W116 that really set the template.

Now, seven generations in, the 2021 S-Class is all-new again, with progressive safety and interior features that should help keep it Australia's bestselling full-sized upper-luxury sedan.

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Deep dive comparison

2025 Lexus NX 2021 Mercedes-Benz S450

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