Audi S5 vs Mercedes-Benz S-Class
What's the difference?

Audi S5

$89,888 - $140,990

2025 price

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Mercedes-Benz S-Class

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2021 price

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Aston Martin Vanquish

Lamborghini Aventador

Mercedes-Benz A-Class

Mercedes-Benz A35

Mercedes-Benz A45

Mercedes-Benz AMG GT

Mercedes-Benz C-Class

Mercedes-Benz CLA-Class

Mercedes-Benz CLA250

Mercedes-Benz CLS-Class

Mercedes-Benz E-Class

Mercedes-Benz E53

Mercedes-Benz GLC-Class

Mercedes-Benz S-Class

Mercedes-Benz SL-Class

Summary

2025 Audi S5

2021 Mercedes-Benz S-Class

By Chris Thompson

By Byron Mathioudakis

Safety Rating

Engine Type

Turbo 4, 2.0L

Twin Turbo V6, 3.0L

Fuel Type

Premium Unleaded/Electric

Premium Unleaded Petrol

Fuel Efficiency

6.9L/100km (combined)

8.4L/100km (combined)

Seating

Likes

Stacked with techy features
Edition One value is hard to deny
Still a delight to drive

S-Class' return to splendour
Stunning high-tech cabin presentation
Outstanding ride and handling capabilities

Dislikes

Loses some interior simplicity
Edition One not a permanent fixture
Having to wait for more variants

Price of entry prohibitive for most
3D instrumentation can make you woozy
A tad conservative in design

2025 Audi S5 Summary

The Audi A5 has done something naughty. It’s replaced the Audi A4.

Or at least that’s the case for now after the Ingolstadt brand made a bit of a mess of its naming strategy.

Essentially, the Audi A5 is now available as a sedan or a wagon, and the next A4 coming soon will be electric. The previous A5 was a swoopier two-door coupe or four-door gran coupe style model. So the A5 is now effectively Audi’s main BMW 3 Series or Mercedes C-Class and CLA rival.

Plus, the Audi S5 is also here to cater to performance car fans.

Can a new platform, a sleek, fresh look and a techy interior do the job?

We’ve been pedalling around the Victorian countryside in the hopes of finding out.

Stick with me, and I reckon we’ll get to the bottom of it. The question about the car, that is, not the bottom of Victoria.

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2021 Mercedes-Benz S-Class Summary

It's only in the running for the title of world's best luxury car. No biggie here, then.

Like Rolex and Concorde, S-Class has become a byword for ultimate, and deserved or not, the Mercedes-Benz defines its segment despite the best efforts of the BMW 7 Series, Audi A8, Lexus LS and (sadly now-defunct) Jaguar XJ, as well as pointing the way forward with new technologies that eventually trickle down to more proletarian models.

Replacing the half-million selling W222 unveiled in 2013, the W223 is the latest in a long line since the first W187 Ponton debuted in 1951, and includes the famous ‘Finnies' and Stroke-8 models that followed immediately afterwards, but it is the 1972 W116 that really set the template.

Now, seven generations in, the 2021 S-Class is all-new again, with progressive safety and interior features that should help keep it Australia's bestselling full-sized upper-luxury sedan.

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Deep dive comparison

2025 Audi S5 2021 Mercedes-Benz S-Class

Verdict

The Audi A5 remains a convincing option in the premium mid-size sedan category, even with the near-$10K price increase over its equivalent grade A4 predecessor.

Even in its base spec, it’s a lovely thing to drive and adds enough new kit to be a reasonable option when it comes to value. In terms of tech usability, it stands out from rivals. Practicality is still king for Audi.

But for the heart-over-head types, the S5 is fast and fun while remaining a comfortable cruiser and the price is decent. On a personal note, a six-cylinder wagon? That's a big yes from me.

For the time it’s available, it’s hard to go past the value on offer in the S5 Edition One. Getting an AWD V6 with that kind of capability for under $100K is something that's sure to tempt buyers. If it doesn’t, we need to take a good look at ourselves.

Note: CarsGuide attended this event as a guest of the manufacturer, with meals provided.

Verdict

Mercedes-Benz set out to restore the S-Class' place amongst the greatest sedans in the world.

In the heavily-optioned, near-$250K-plus S450 as well as the extended S450L at $300K as tested (the sweet spot of the range for now), we reckon the Germans have succeeded, pushing safety, comfort and technology boundaries, in a package that is true to the heritage of the series.

Tax-fuelled sky-high prices will certainly keep the S-Class niche in Australia, but the car is more than good enough to dominate its tiny corner of the upper-large luxury car sphere.

The best new car in the world? We reckon it's highly likely. Mission accomplished, Mercedes.

Audi S5 vs Mercedes-Benz S-Class What's the difference?

Summary

Deep dive comparison

Verdict

Verdict

Audi S5 vs Mercedes-Benz S-Class
What's the difference?