Wheel size for the 2025 Mercedes-Benz S450 will vary depending on model chosen, although keep in mind that many manufacturers offer alternate wheel sizes as options on many models. The wheel size available will alter the range of tyres available to be fitted.

The 2025 Mercedes-Benz S450 has maximum towing capacity of 2100kg. Some models also offer heavy-duty or towing option packs which can increase towing capacity, as well as options which can hamper towing capacity. Towing capacities can vary wildly on a large number of factors. These include engine, transmission, model, and options chosen. Always check with the manufacturer or in your vehicles handbook before attempting to tow anything.

Fuel consumption for the 2025 Mercedes-Benz S450 is dependent on the type of engine, transmission, or model chosen. The Mercedes-Benz S450 currently offers fuel consumption from 8.9L/100km.