Is my Mercedes E350 Coupe a high-mileage example?

Not really, and modern cars have proven they should be easily able to cover this distance with plenty of life left in them. That, however, is on the proviso they’ve been serviced and maintained correctly.

Even the best, most robust cars can fail long before 169,000km if they’ve been neglected, particularly with regard to oil changes. So the real answer to your question will depend on the car’s service history. Check the history carefully for any signs of skipped servicing. We’d buy a high-mileage car with a full history over a low-mileage example with no records every time.